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GLP-1 (glucagon-like peptide-1) receptor agonists are a class of prescription-only medicines used to support weight management. Currently available in injectable form, following assessment by a clinician.
Oral GLP-1 tablets are being developed and studied as once-daily tablet formulations for weight management. These medicines work by mimicking the GLP-1 hormone, which can help regulate appetite and food intake.
Treatment suitability, availability and prescribing decisions are determined by a clinician following an appropriate consultation.
Tablet-based weight loss treatments
Contain a GLP-1 receptor agonist (the same active ingredient as Wegovy)
Taken once daily, rather than once weekly by injection
Clinically tested with results comparable to injectable options
An option for people who would prefer not to inject
Convenient for those with busy or unpredictable routines
No need for refrigerated storage or injection supplies
The same clinically supported approach, in a familiar tablet format
Two large clinical trials give us the best picture so far. Here's what happened when real patients took oral GLP-1 tablets alongside diet and lifestyle support.
average body weight lost over 64 weeks
In a study of 307 adults – that's roughly 1 in 4 losing 20% or more of their body weight.
average body weight lost over 74 weeks
In a study of 3,127 adults – over half lost at least 10% of their body weight.
* Averages from clinical trials in controlled settings alongside diet and lifestyle support. Individual results will vary.
* The two trials used different designs and durations and cannot be directly compared with each other.
* Both treatments are not yet available in the UK. Availability is subject to regulatory approval. Both expected in 2026.
Oral GLP-1 tablets and injectable GLP-1 treatments are both effective, clinically-proven options. The right choice depends on your personal preferences and circumstances. Here is a quick comparison:
* Averages from clinical trials in controlled settings alongside diet and lifestyle support. Individual results will vary.
* The two trials used different designs and durations and cannot be directly compared with each other.
* Both treatments are not yet available in the UK. Availability is subject to regulatory approval. Both expected in 2026.
Clinician-led care: as with all Morrisons Clinic treatments, you will receive ongoing support from our UK-registered clinical team
No need to keep checking: we will do the monitoring and reach out when there is a meaningful update
Trusted by thousands of patients: Morrisons Clinic is powered by Phlo, a GPhC-regulated pharmacy
Expert guidance: our clinicians will help you understand whether oral GLP-1 treatment is right for you when it becomes available
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Like all medicines, oral GLP-1 tablets can cause side effects. Most are digestive and tend to be mild to moderate, often settling down as your body adjusts during the first few weeks of treatment.
*This information is based on phase 3 clinical trial data and US prescribing information.
This is not a complete list of side effects. Always consult a qualified clinician before starting treatment.
Morrisons Clinic
Unit 1 Fifth Street
Trafford Park
Manchester
England
M17 1JX
Dennis Ouko
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